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Chronicles

Exploring the valleys of the skin: A new perspective on the relevance of skin models in research

Apr 28, 2026 | Chronicles

SkinChronicles, No 12, April 2026, by April Rose Foster A fascinating new publication from the Driskell lab led by Sean Thompson et al brings two key ideas: i) a distinct molecular mechanism in the development of rete ridge network driven by BMP signalling and ii)...

Resident cytotoxic CD8+ T cells and keratinocyte antigen presentation amplify SJS/TEN lesions

Mar 17, 2026 | Chronicles

SkinChronicles, No 11, March 2026, by Haruna Kimura Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare, severe cutaneous adverse reaction characterized by extensive keratinocyte death and epidermal detachment, yet the lesion-level immune circuitry...

Confirming Risk, Expanding the Question: Lichen Sclerosus and Squamous Cell Carcinoma

Feb 17, 2026 | Chronicles

SkinChronicles, No 10, February 2026, by Alessia Paganelli For decades, clinical observations and smaller cohort studies have suggested that lichen sclerosus (LS) carries an increased risk of squamous cell carcinoma (SCC), particularly of the vulva. However, the true...

Molecular Skin Mapping: Spatial Proteomics in Basic and Translational Dermatology

Jan 12, 2026 | Chronicles

SkinChronicles, No 9, January 2026, by Lavanya Moparthi Mass spectrometry–based spatial proteomics is an emerging approach that provides deeper molecular insights into biological processes at single‑cell resolution in situ. Nordmann and colleagues have advanced...

The underestimated role of epidermal keratinocytes in interferon β production during psoriasis and skin injury

Nov 17, 2025 | Chronicles

SkinChronicles, No 8, November 2025, by Florence Assan Keratinocytes were known to participate in skin inflammatory responses by releasing proinflammatory cytokines such as IL-6, IL-8, and TNFα. In contrast, the production of type I interferons (IFNs) has...

Architectural Rewiring of the 3D Genome During Epidermal Differentiation

Jun 10, 2025 | Chronicles

ESDR SkinChronicles, No. 7, June 2025, by Yaarob Altalli, MSc “Architectural Rewiring of the 3D Genome During Epidermal Differentiation” The mammalian nucleus condenses ~2 meter of DNA into a ~10 micrometre sphere, balancing extreme compaction with local...
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