The Institute of In vivo and In vitro Models belongs to the University of Veterinary Medicine Vienna. The main scientific focus of the institute is to understand the role of the ERBB receptor system during tissue homeostasis and during pathogenesis. We are studying the ERBB receptor system on the basis of genetically modified in vivo mouse models, as well as in vitro in different cell culture models. We focused our studies on the homeostasis and development of the skin and gastrointestinal tract and in investigations of the ERBB receptors in psoriasis, non-melanoma-skin-cancer, as well as pancreatitis and pancreatic ductal adenocarcinoma.
My group is also highly interested in molecules, which are regulating the ERBB system. Different environmental conditions or diseases can disturb the ERBB signaling cascade and this results in positive and negative feedback loops, which stabilize the system again. Recently, the leucine-rich repeats and immunoglobulin-like domains (LRIG) family attracted our attention because of their influence on these feedback mechanisms. In this project we will investigate how the LRIG proteins interact with the ERBB system and how it alters the skin phenotype in different mouse models as well as human tissue. It is not known, how the LRIG-ERBB network is working in detail and this knowledge is important to understand ERBB-receptor biology and furthermore it can help us to develop new molecular drugs for different diseases. In particular, we want to use the LRIG proteins to regulate ERBB receptors in the epidermis during skin homeostasis and diseases.
|Job Category||Postdoc/ Scientist|
Contact /Further Information Univ.-Prof. Dr. Maik Dahlhoff T: +43 25077-2800 Email: firstname.lastname@example.org Website: www.vetmeduni.ac.at/labortierkunde