Journal Of Investigative Dermatology

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Table of Contents

Sat, 2018-09-01 00:00

Subscription Information

Sat, 2018-09-01 00:00

Editorial Board

Sat, 2018-09-01 00:00

Cells to Surgery Quiz: September 2018

Sat, 2018-09-01 00:00
Editorial note: Welcome to the Journal of Investigative Dermatology (JID) Cells to Surgery Quiz. In this monthly online-only quiz, the first question (“What is your diagnosis?”) relates to the clinical image above, while additional questions concern the findings reported in a JID article that provides new information about that disease entity.

Editors’ Picks

Sat, 2018-09-01 00:00
Sequencing of the T cell receptor (TCR) of single cells can be useful for lineage tracing in either the normal immune response or in the context of malignancy. Satpathy and colleagues recently reported the robust and reproducible application of the combination of sequencing of TCRs with an assay for transposase-accessible chromatin with sequencing (T-ATAC-seq) to primary and immortalized T cells. This analysis paired epigenomic identification of cis and trans determinants of cell identity with RNA sequences of TCR genes, allowing mapping of single-cell chromatin states and immune cell phenotypes.

Clinical Snippets

Sat, 2018-09-01 00:00
Following on the heels of the 2017 Medical Board of the National Psoriasis Foundation recommendations for achieving clear or almost clear skin as the standard of care, Merola and colleagues assessed the potential of body surface area (BSA) and BSA x static Physician Global Assessment (sPGA) as proxy measures for the Psoriasis Area and Severity Index (PASI), which has been used for clinical practice decisions despite its cumbersome nature. In a pooled sample of 3,886 patients, BSA and BSA x sPGA proved sufficient, especially for high clinical response.

Erratum

Sat, 2018-09-01 00:00
Uncommon Filaggrin Variants Are Associated with Persistent Atopic Dermatitis in African Americans

Saturated Fatty Acids as Possible Key Amplifiers of Psoriatic Dermatitis

Sat, 2018-09-01 00:00
The association of obesity with psoriasis is well known, but the molecular link between these two entities is incompletely characterized. Herbert et al. report that dietary saturated fatty acids, rather than obesity itself, promote exacerbation of psoriasis in high fat diet-induced obesity. They also suggest that dietary manipulation could improve psoriasis.

Addendum

Sat, 2018-09-01 00:00
SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

Erratum

Sat, 2018-09-01 00:00
Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation

Diversity and Inclusion: The Right Initiative and a Smart Initiative for the Society for Investigative Dermatology

Sat, 2018-09-01 00:00
The Society for Investigative Dermatology (SID) and similar organizations have been grappling with inclusion and diversity issues for decades and, in some sense, since their inceptions. Membership has never been universal, and the makeup of the SID over time has reflected broader social forces well outside the control of the organization. Leadership of scientific organizations, such as the SID, recognized early on the essential need to attract and retain new members. However, there is always a tension between welcoming the new and the potential for change versus the desire to preserve what is viewed as timeless and important.

Erratum

Sat, 2018-09-01 00:00
Whole-Exome Sequencing of Acquired Nevi Identifies Mechanisms for Development and Maintenance of Benign Neoplasms

Erratum

Sat, 2018-09-01 00:00
NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types

Research Techniques Made Simple: Genome-Wide Homozygosity/Autozygosity Mapping Is a Powerful Tool for Identifying Candidate Genes in Autosomal Recessive Genetic Diseases

Sat, 2018-09-01 00:00
Homozygosity mapping (HM), also known as autozygosity mapping, was originally used to map genes underlying homozygous autosomal recessive Mendelian diseases in patients from closely genetically related populations, followed by Sanger sequencing. With the increase in use of next-generation sequencing approaches, such as whole-exome sequencing and whole-genome sequencing, together with advanced bioinformatics filtering approaches, HM is again emerging as a powerful method for the identification of genes involved in disease etiology.

Keyword Index

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AcneLB1508, LB1516, LB1557, LB1569, LB1570, LB1585

Author Index

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Ahmatova, LiisiLB1556

Late-Breaking Abstracts Title Page

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Late-Breaking Abstracts

LB1616 EpiX™ expansion technology enables in vitro tissue engineering of skin using autologous patient-derived cells for regenerative medicine applications

Sat, 2018-09-01 00:00
It remains a challenge to preserve stem and progenitor cells during expansion of epidermal keratinocytes ex vivo under serum-free and feeder-cell-free culture condition. This limitation greatly hinders the development of advanced autologous cell and gene therapeutics for inherited skin diseases such as epidermolysis bullosa and injuries such as severe burns. We have developed a serum-free and feeder-cell-free culture technology (EpiX™) that allows rapid generation of more than one-trillion epidermal keratinocytes while retaining the stem and progenitor cell population.

LB1615 Role of linoleic fatty acid in the in vitro modulation of the angiogenic process

Sat, 2018-09-01 00:00
Angiogenesis is defined as the formation of new blood vessels from existing vessels, and it is involved in physiological and pathological processes. This complex event is regulated by various pro/anti angiogenic molecules, such as the vascular endothelial growth factor (VEGF). Wound healing is a condition in which angiogenesis plays an important role, since the formation of new vessels is essential for the arrival of inflammatory cells, removal of cellular debris, and the adequate supply of oxygen and nutrients to the injured site.

LB1614 Phagocytosis by M2 macrophages drives chronic Wnt activity for a fibrotic skin wound healing fate

Sat, 2018-09-01 00:00
Human and murine skin wounding usually result in fibrotic scarring. However large wounding, as exemplified in the murine model Wound Induced Hair Neogenesis (WIHN), can result in either regenerative repair, replete with hair neogeneis, or in fibrotic scarring, with all the hallmarks of that condition. We have compared these healing fates in the WIHN model to show that M2 macrophages are requisite for dermal remodeling and regeneration but higher numbers promote chronic myofibroblast Wnt activity and fibrogenesis.

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