Journal Of Investigative Dermatology

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Factors related to nevus-associated cutaneous melanoma: a case-case study

Wed, 2018-03-07 00:00
A proportion of cutaneous melanomas display neval remnants on histologic examination. Converging lines of epidemiologic and molecular evidence suggest that melanomas arising from nevus precursors differ from melanomas arising de novo. In a large, population-based study comprising 636 cutaneous melanomas subjected to dermatopathology review, we explored the molecular, host and environmental factors associated with the presence of neval remnants. We found nevus-associated melanomas were significantly associated with younger age at presentation, non-brown eye color, trunk site, thickness <0.5mm and BRAFV600E mutation.

Factors related to nevus-associated cutaneous melanoma: a case-case study

Wed, 2018-03-07 00:00
A proportion of cutaneous melanomas display neval remnants on histologic examination. Converging lines of epidemiologic and molecular evidence suggest that melanomas arising from nevus precursors differ from melanomas arising de novo. In a large, population-based study comprising 636 cutaneous melanomas subjected to dermatopathology review, we explored the molecular, host and environmental factors associated with the presence of neval remnants. We found nevus-associated melanomas were significantly associated with younger age at presentation, non-brown eye color, trunk site, thickness <0.5mm and BRAFV600E mutation.

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